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Abstract Stem cells are a promising solution for repaired damage tissue. Isolation of this cell from tissue, proliferation in vitro, and implanting them in damaged tissue microenvironment are the basic strategy of Regenerative medicine. Mesenchymal stem cells (MSCs) have unique therapeutics function such as homing to target tissue and stimulating host cell regeneration, repairing damaged cells, autocrine/paracrine effects, immune modulation and several lineages differentiation. For this reason, MSCs are appropriate choice for tissue engineering and cell based therapy. Umbilical cord as a commonly discarded tissue, which are obtained non-invasively. Umbilical cord contains Wharton’s jelly (WJ), a gelatin substance surrounding umbilical cord vessels. WJ, a rich source of self-renewal MSCs with extended proliferation and multilineage differentiation potential can be a best option for Regenerative medicine based on celltherapy. In this chapter, we will discuss an outline of the recent findings related to Wharton’s jelly Mesenchymal stem cells (WJ- MSCs) and its therapeutic effects and possible advantage they possess.