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Abstract Our work is based on the multiple inequalities illustrated by Boudeliou and Khalaf in 2015. With the help of the Leibniz integral rule on time scales, we generalize a number of those inequalities to a general time scale. Besides that, in order to obtain some new inequalities as special cases, we also extend our inequalities to discrete, quantum, and continuous calculus. These inequalities may be of use in the analysis of some kinds of partial dynamic equations on time scales and their applications in environmental phenomena, physical and engineering sciences described by partial differential equations.