SARS-CoV-2 variants: Subversion of antibody response and predicted impact on T cell recognition
oleh: Daniel M. Altmann, Catherine J. Reynolds, Rosemary J. Boyton
| Format: | Article |
|---|---|
| Diterbitkan: | Elsevier 2021-05-01 |
Deskripsi
COVID-19 variants of concern, including B.1.1.7, B.1.351, and P.1, encompass mutations facilitating immune evasion. Neutralizing antibody recognition and function may be variably impaired. We considered the impact of mutations on T cell responses. Mutations could be neutral or result in either loss or gain of predicted epitopes depending on HLA type.