Imputation-powered whole-exome analysis identifies genes associated with kidney function and disease in the UK Biobank
oleh: Matthias Wuttke, Eva König, Maria-Alexandra Katsara, Holger Kirsten, Saeed Khomeijani Farahani, Alexander Teumer, Yong Li, Martin Lang, Burulca Göcmen, Cristian Pattaro, Dorothee Günzel, Anna Köttgen, Christian Fuchsberger
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2023-03-01 |
Deskripsi
An exome wide association study of UK Biobank data revealed 158 variants and 105 genes significantly associated with kidney function traits and disease. The findings are supported by functional evidence for a previously unreported mutation in CLDN10.