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<p><strong>BACKGROUND: </strong>ABO blood groups are genetically transmitted through chromosome 9 at locus 9q34. It is supposed that there is a locus on 9p21, which has a role in developing coronary artery disease.</p> <p><strong>METHODS:</strong> Our study population consisted of 309 patients with unstable angina admitted to the Ziaeian Hospital, Tehran, Iran, who underwent coronary angiography. The<strong> </strong>association between types of blood group (O and non-O) with the severity of coronary artery disease was investigated.</p> <p><strong>RESULTS</strong>: Compared to the non-O groups, the O group had more severe coronary artery involvement (P = 0.004).</p> <p><strong>CONCLUSION:</strong> Our study supports recent suggestions on the association between blood group and coronary artery disease. Further studies are needed to evaluate the effect of blood group on atherosclerosis.&nbsp;</p><p>&nbsp;</p>