The manatee variational autoencoder model for predicting gene expression alterations caused by transcription factor perturbations
oleh: Ying Yang, Lucas Seninge, Ziyuan Wang, Anthony Oro, Joshua M. Stuart, Hongxu Ding
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2024-05-01 |
Deskripsi
Abstract We present the Manatee variational autoencoder model to predict transcription factor (TF) perturbation-induced transcriptomes. We demonstrate that the Manatee in silico perturbation analysis recapitulates target transcriptomic phenotypes in diverse cellular lineage transitions. We further propose the Manatee in silico screening analysis for prioritizing TF combinations targeting desired transcriptomic phenotypes.