Can Enterocin M in Combination with Sage Extract Have Beneficial Effect on Microbiota, Blood Biochemistry, Phagocytic Activity and Jejunal Morphometry in Broiler Rabbits?
oleh: Monika Pogány Simonová, Ľubica Chrastinová, Anna Kandričáková, Soňa Gancarčíková, Eva Bino, Iveta Plachá, Jana Ščerbová, Viola Strompfová, Rudolf Žitňan, Andrea Lauková
| Format: | Article |
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| Diterbitkan: | MDPI AG 2020-01-01 |
Deskripsi
The present study investigated the effects of enterocin (Ent) M and sage extract alone and also in combination on the gut microflora, phagocytic activity, blood biochemistry, and morphometry of rabbits. Sixty-four rabbits (aged five weeks, M91 meatline, both sexes) were divided into three experimental groups: E (EntM; 50 µL/animal/day), S (sage; 10 µL/animal/day), and E + S (EntM + sage) groups and control group (C). The additives were administered in drinking water for a period of 21 days. Dietary supplementation of EntM and sage significantly reduced the coliforms (E: <i>p</i> < 0.001; S: <i>p</i> < 0.001; E + S: <i>p</i> < 0.001) in feces, while simultaneous addition of EntM and sage decreased enterococci (E + S: <i>p</i> < 0.0001), lactic acid bacteria (E + S: <i>p</i> < 0.01), and coagulase-positive staphylococci (E + S: <i>p</i> < 0.0001) in the appendix. Sage addition reduced HDL (S: <i>p</i> < 0.001) and LDL cholesterol (S: <i>p</i> < 0.001; E + S: <i>p</i> < 0.001), LDL/HDL ratio (S: <i>p</i> < 0.001; E + S: <i>p</i> < 0.01), and increased urea (S: <i>p</i> < 0.01; E + S: <i>p</i> < 0.001) and creatinine (S: <i>p</i> < 0.001; E + S: <i>p</i> < 0.001) in serum. EntM and sage application, alone or in combination, improve the jejunal morphometry (<i>p</i> < 0.0001) in rabbits.