Soluble RANKL contributes to osteoclast formation in adult mice but not ovariectomy-induced bone loss
oleh: Jinhu Xiong, Keisha Cawley, Marilina Piemontese, Yuko Fujiwara, Haibo Zhao, Joseph J. Goellner, Charles A. O’Brien
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-07-01 |
Deskripsi
RANKL is a cytokine produced as a membrane-bound and a secreted protein. Here, using mice lacking soluble RANKL, the authors show that the secreted protein is important for osteoclast function, but not for mammary gland and lymphocyte development.