C. elegans monitor energy status via the AMPK pathway to trigger innate immune responses against bacterial pathogens
oleh: Shouyong Ju, Hanqiao Chen, Shaoying Wang, Jian Lin, Yanli Ma, Raffi V. Aroian, Donghai Peng, Ming Sun
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-06-01 |
Deskripsi
Bacillus thuringiensis toxin Cry5Ba triggers potassium ion leakage, causing mitochondrial damage and energy imbalance. C. elegans can monitor this intracellular energy imbalance via AMP-activated protein kinase to trigger innate immune responses.