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Cancer-related fatigue can continue long after curative cancer treatment. The aim of this study was to investigate sleep and rest–activity cycles in fatigued and non-fatigued cancer survivors. We hypothesized that sleep and rest–activity cycles would be more disturbed in people experiencing clinically-relevant fatigue, and that objective measures of sleep would be associated with the severity of fatigue in cancer survivors. Cancer survivors (<i>n</i> = 87) completed a 14-day wrist actigraphy measurement to estimate their sleep and rest–activity cycles. Fatigue was measured using the Functional Assessment of Chronic Illness Therapy Fatigue Scale (FACIT-F). Participants were dichotomised into two groups using a previously validated score (fatigued <i>n</i> = 51 and non-fatigued <i>n</i> = 36). The participant’s perception of sleep was measured using the Insomnia Severity Index (ISI). FACIT-F score was correlated with wake after sleep onset (<i>r</i> = −0.28; <i>p</i> = 0.010), sleep efficiency (<i>r</i> = 0.26; <i>p</i> = 0.016), sleep onset latency (<i>r</i> = −0.31; <i>p</i> = 0.044) and Insomnia Severity Index (ISI) score (<i>r</i> = −0.56; <i>p</i> < 0.001). The relative amplitude of the rest–activity cycles was lower in the fatigued vs. the non-fatigued group (<i>p</i> = 0.017; <i>d</i> = 0.58). After treatment for cancer, the severity of cancer-related fatigue is correlated with specific objective measures of sleep, and there is evidence of rest–activity cycle disruption in people experiencing clinically-relevant fatigue.