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A chemoenzymatic synthesis of ceramide trafficking inhibitor HPA-12
oleh: Seema V. Kanojia, Sucheta Chatterjee, Subrata Chattopadhyay, Dibakar Goswami
Format: | Article |
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Diterbitkan: | Beilstein-Institut 2019-02-01 |
Deskripsi
A chemoenzymatic synthesis of the title compound has been developed using an efficient and highly enantioselective lipase-catalyzed acylation in a hydrophobic ionic liquid, [bmim][PF6], followed by a diastereoselective asymmetric dihydroxylation as the key steps for incorporating the stereogenic centers. The further conversion to the appropriate intermediates and subsequent acylation with lauric acid furnished the target compound.