A chemoenzymatic synthesis of ceramide trafficking inhibitor HPA-12

oleh: Seema V. Kanojia, Sucheta Chatterjee, Subrata Chattopadhyay, Dibakar Goswami

Format: Article
Diterbitkan: Beilstein-Institut 2019-02-01

Deskripsi

A chemoenzymatic synthesis of the title compound has been developed using an efficient and highly enantioselective lipase-catalyzed acylation in a hydrophobic ionic liquid, [bmim][PF6], followed by a diastereoselective asymmetric dihydroxylation as the key steps for incorporating the stereogenic centers. The further conversion to the appropriate intermediates and subsequent acylation with lauric acid furnished the target compound.