Stereoselective OsO4-mediated dihydroxylation of β-substituted α-trialkylsilyl-β,γ-unsaturated esters
oleh: Anna C. Seal, Michael P. Jennings
| Format: | Article |
|---|---|
| Diterbitkan: | Elsevier 2021-01-01 |
Deskripsi
The dihydroxylation of various of α-trialkylsilyl-β,γ-unsaturated esters with OsO4 and NMO has been explored. It has been revealed that these reactions readily allow for a stereoselective dihydroxylation with high levels of dr (>20/1) to afford anti-aldol products with three contiguous stereogenic centers in modest overall yields.