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Neutrophil extracellular traps and complications of liver transplantation
oleh: Yanyao Liu, Ping Yan, Yue Bin, Xiaoyan Qin, Xiaoyan Qin, Zhongjun Wu
Format: | Article |
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Diterbitkan: | Frontiers Media S.A. 2022-11-01 |
Deskripsi
Many end-stage liver disease etiologies are attributed to robust inflammatory cell recruitment. Neutrophils play an important role in inflammatory infiltration and neutrophil phagocytosis, oxidative burst, and degranulation. It has also been suggested that neutrophils may release neutrophil extracellular traps (NETs) to kill pathogens. It has been proven that neutrophil infiltration within the liver contributes to an inflammatory microenvironment and immune cell activation. Growing evidence implies that NETs are involved in the progression of numerous complications of liver transplantation, including ischemia-reperfusion injury, acute rejection, thrombosis, and hepatocellular carcinoma recurrence. NETs are discussed in this comprehensive review, focusing on their effects on liver transplantation complications. Furthermore, we discuss NETs as potential targets for liver transplantation therapy.