Omics analysis of Mycobacterium tuberculosis isolates uncovers Rv3094c, an ethionamide metabolism-associated gene
oleh: Li Wan, Peilei Hu, Lili Zhang, Zhao-Xi Wang, Joy Fleming, Bo Ni, Jianjun Luo, Cha-Xiang Guan, Liqiong Bai, Yunhong Tan, Haican Liu, Na Li, Tongyang Xiao, Hua Bai, Yong-An Zhang, Xian-En Zhang, Kanglin Wan, Lijun Bi, Songying Ouyang, Hongtai Zhang
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2023-02-01 |
Deskripsi
A multi-omic analysis of 11 Mycobacterium tuberculosis (Mtb) isolates with different drug resistance profiles leads to the discovery of Rv3094c, an enzyme capable of activating the clinically relevant Mtb drug, ethionamide.