N7-methylguanosine tRNA modification promotes esophageal squamous cell carcinoma tumorigenesis via the RPTOR/ULK1/autophagy axis
oleh: Hui Han, Chunlong Yang, Jieyi Ma, Shuishen Zhang, Siyi Zheng, Rongsong Ling, Kaiyu Sun, Siyao Guo, Boxuan Huang, Yu Liang, Lu Wang, Shuang Chen, Zhaoyu Wang, Wei Wei, Ying Huang, Hao Peng, Yi-Zhou Jiang, Junho Choe, Shuibin Lin
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2022-03-01 |
Deskripsi
Deregulation of METTL1-mediated N7- methylguanosine tRNA modification can promote oncogenesis. Here, the authors report that this modification regulates the translation of proteins in both the mTOR and negative regulators of autophagy pathways, resulting in the progression of esophageal squamous cell carcinoma.