Reversible Myc hypomorphism identifies a key Myc-dependency in early cancer evolution

oleh: Nicole M. Sodir, Luca Pellegrinet, Roderik M. Kortlever, Tania Campos, Yong-Won Kwon, Shinseog Kim, Daniel Garcia, Alessandra Perfetto, Panayiotis Anastasiou, Lamorna Brown Swigart, Mark J. Arends, Trevor D. Littlewood, Gerard I. Evan

Format: Article
Diterbitkan: Nature Portfolio 2022-11-01

Deskripsi

Happloinsufficiency of Myc delays onset of cancers in mice. Here, the authors generated a mouse model of reversible cMyc hypomorphism and show that metronomic reduction of c-Myc in adult mice confers protection against cancers without side effects and that the bottleneck in early cancer evolution is dependent upon Myc.