Piezo2 expressed in proprioceptive neurons is essential for skeletal integrity
oleh: Eran Assaraf, Ronen Blecher, Lia Heinemann-Yerushalmi, Sharon Krief, Ron Carmel Vinestock, Inbal E. Biton, Vlad Brumfeld, Ron Rotkopf, Erez Avisar, Gabriel Agar, Elazar Zelzer
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-06-01 |
Deskripsi
Mutations in human PIEZO2, encoding for a mechanosensitive ion channel, lead to skeletal abnormalities including scoliosis and hip dysplasia. Here, the authors show that deletion of Piezo2 in proprioceptive neurons, but not in skeletal lineages, recapitulated the human phenotype in mice.