A neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models
oleh: Giulia E. Tyzack, Claire E. Hall, Christopher R. Sibley, Tomasz Cymes, Serhiy Forostyak, Giulia Carlino, Ione F. Meyer, Giampietro Schiavo, Su-Chun Zhang, George M. Gibbons, Jia Newcombe, Rickie Patani, András Lakatos
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-10-01 |
Deskripsi
Astrocytes can have protective or detrimental effects on neurons during injury, but the molecular mechanisms that determine these different states are unresolved. Here the authors identify a pathway via neuronal EphB1 that induces neuroprotective signalling in astrocytes through ephrin-B1 mediated STAT3 activation, which is impaired in models of amyotrophic lateral sclerosis.