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The book Yi Xue Shi (《医学史》 History of Medicine) was written and edited by Cecilia Mettler and Fred Mettler couple, published in 1947. The book is about the literature research of systematic introduction to the history of medical development worldwide. The book provides a detailed description of the development of various medical disciplines and subjects through various documents and the authors and publication dates. Especially, Prof. Mettler has introduced the Chinese Yin and Yang (阴阳) and the five element theory (五行学说) and Shen Nung's Materia Medica (神农本草) in this book.