Live-cell p53 single-molecule binding is modulated by C-terminal acetylation and correlates with transcriptional activity
oleh: Alessia Loffreda, Emanuela Jacchetti, Sofia Antunes, Paolo Rainone, Tiziana Daniele, Tatsuya Morisaki, Marco E. Bianchi, Carlo Tacchetti, Davide Mazza
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-08-01 |
Deskripsi
Both transcription binding kinetics and post-translational modifications of transcription factors are thought to play a role in the modulation of transcription. Here the authors use single-molecule tracking to directly demonstrate that p53 acetylation modulates promoter residence time and transcriptional activity.