Conformational switching within dynamic oligomers underpins toxic gain-of-function by diabetes-associated amyloid
oleh: Melissa Birol, Sunil Kumar, Elizabeth Rhoades, Andrew D. Miranker
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-04-01 |
Deskripsi
Toxic gain-of-function by islet amyloid polypeptide (IAPP) is thought to be mediated by membrane poration. Here the authors develop diluted-FRET to show that changes in pore structure correlate with onset of toxicity inside insulin secreting cells.