Targeting tumor vulnerabilities associated with loss of heterozygosity
oleh: Veronica Rendo, Ivaylo Stoimenov, Tobias Sjöblom
| Format: | Article |
|---|---|
| Diterbitkan: | Taylor & Francis Group 2020-07-01 |
Deskripsi
We show that N-acetyltransferase 2 (NAT2) loss of heterozygosity can be targeted in >4% of colorectal cancers with the use of a small molecule. We identify and describe the effect of a compound that impairs the growth of colorectal tumors with slow NAT2 activity by half when compared to wild-type.