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Immune Protective Efficacy of China’s Traditional Inactivated and Attenuated Vaccines against the Prevalent Strains of <i>Pasteurella multocida</i> in Mice
oleh: Li-Jun Guan, Ji-Jian Song, Yun Xue, Xia Ai, Zhi-Jun Liu, Li-Fang Si, Meng-Yun Li, Zhan-Qin Zhao
Format: | Article |
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Diterbitkan: | MDPI AG 2021-10-01 |
Deskripsi
Capsular type A and D strains of <i>Pasteurella multocida</i> are the main epidemic serogroups in pigs in China. In this study, we preliminarily evaluated the immune protective efficacy of the two traditional vaccines, an inactivated C44-1 aluminum-hydroxide-gel-adjuvanted (Alh–C44-1) vaccine and a live EO630 vaccine, against currently circulating strains of <i>P. multocida</i> in a mouse model. Mice immunized twice with conventional vaccines generated higher antibody titers, and significantly higher levels of IgG were observed in the mice inoculated with the inactivated Alh–C44-1 vaccine on day 35 (<i>p</i> < 0.05) than those with the live EO630 vaccine. The mice immune protection test showed that the vaccination groups had a 57% or 71% protection effect against the serogroup B strain, but had no protective effect against epidemic strains. In conclusion, our study found that the widely used traditional <i>P. multocida</i> vaccines in China provide good protection against homologous strains, but could not provide cross-protection against heterologous strains in a mouse model.