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Objectives: The susceptibilities of ESBL-producing E.coli and K. pneumoniae to ertapenem, meropenem and piperacillin-tazobactam.53 strains of E.coli and K. pneumoniae were studied.  Methods: They were originally resistant to ceftazidine.  Minimum inhibitory concentration of the strains towards ertapenem, meropenem and piperacillin-tazobactam were determined by Vitek-2 compact system. Results: The MICs of all ertapenem and meropenem for all isolates were <0.5 mg/ml and <0.25 mg/ml respectively and MIC of piperacillin-tazobactam was between 4 to 16 mg/ml. ESBL-producing organisms were more susceptible to ertapenem and meropenem.  They were susceptible to piperacillin-tazobactam thus in our hospital ertapenem, meropenem and piperacillin-tazobactam are drugs of choice for them.