A New Geldanamycin Analogue from Streptomyces hygroscopicus

oleh: Hao Zhang, Guang-Zhi Sun, Xiang Li, Hong-Yu Pan, Yan-Sheng Zhang

Format: Article
Diterbitkan: MDPI AG 2010-03-01

Deskripsi

A new geldanamycin analogue was isolated from Streptomyces hygroscopicus A070101. The structure was elucidated as 11-methoxy-17-formyl-17-demethoxy-18-O-21-O-dihydrogeldanamycin (1) on the basis of extensive 1D and 2D NMR as well as HRESI-MS spectroscopic data analysis. Compound 1 showed considerable cytotoxicity (SRB) against human cancer cell lines (breast cancer MCF-7, skin melanoma SK-MEL-2 and lung carcinoma COR-L23).