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Introduction & Objective: Insulin injection is the main way to combat against insulin-dependent diabetes mellitus effects. Today in some laboratories in the world, the investigators are trying to find some treatments for this disease with insulin-secreting pancreatic islet cells transplantation. Encapsulation of pancreatic islet cells allows for transplantation in the absence of immunosuppression. This technique that is called immunoisolation is based on the principle that transplanted tissue is protected for the host immune system by an artificial or natural membrane. Materials & Methods : Donor tissues in each step of work prepared from 6 adult male Wistar Rat with weight 250-300 grams (75-90 days). Transplantation were done in rats after 2-4 week induced diabetes with 60mg/ml streptozotocin injection via intravenous Results: The data obtained from this study showed that islet cells can be enclosed in a semi permeable membrane that permits oxygen and nutrients to reach the islets, allowing insulin to be released into the blood stream and at the same time excluding potentially destructive immune cells and antibodies. Conclusion: Testis subcutaneous and intrapretonea implantation of pure islet cells graft, that is a natural immunoisolation method, rapidly and permanently normalized the diabetic state of streptozocin-administered animals