Find in Library

Recent studies have identified a subtype of the S1P-receptor family called sphingosine-1-phosphate receptor 2 (S1PR2), which plays a crucial role in maintaining the skin barrier. It has been observed that S1PR2 and <i>Staphylococcus epidermidis</i> (<i>S. epidermidis</i>) work together to regulate the skin barrier. However, the interaction between these two factors is still unclear. To investigate this, a study was conducted on healthy skin and allergic contact dermatitis (ACD) using 3,4-Dibutoxy-3-cyclobutene-1,2-dione (SADBE) on the ears of <i>S1pr2^fl/f</i>^l and <i>S1pr2^fl/f</i>^l<i>K14-Cre</i> mice and using 1 × 10⁶ CFU of <i>S. epidermidis</i> to examine its effects on the skin. The results showed that in <i>S. epidermidis</i>-conditioned ACD, the ear thickness of <i>S1pr2^fl/f</i>^l<i>K14-Cre</i> mice was lower than that of <i>S1pr2^fl/f</i>^l mice, and mRNA expressions of <i>Il-1β</i> and <i>Cxcl2</i> of <i>S1pr2^fl/f</i>^l<i>K14-Cre</i> mice were lower than that of <i>S1pr2^fl/f</i>^l mice in ACD with <i>S. epidermidis</i>. Furthermore, the gene expression of <i>Claudin-1</i> and <i>Occludin</i> in <i>S1pr2^fl/f</i>^l<i>K14-Cre</i> mice was higher than that of <i>S1pr2^fl/f</i>^l mice in ACD with <i>S. epidermidis</i>. The study concludes that <i>S. epidermidis</i> colonization improves the skin barrier and prevents ACD even when S1P signaling malfunctions.