Ni-catalyzed asymmetric hydrogenation of N-aryl imino esters for the efficient synthesis of chiral α-aryl glycines
oleh: Dan Liu, Bowen Li, Jianzhong Chen, Ilya D. Gridnev, Deyue Yan, Wanbin Zhang
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-11-01 |
Deskripsi
Chiral α-amino acids find application in the fields of pharmaceutical, biological and synthetic chemistry. Here, the authors report a nickel-catalyzed asymmetric hydrogenation of N-aryl imino esters affording chiral α-aryl glycines in high yields and enantioselectivities.