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Given the recognized involvement of the gut microbiome in the development of obesity, considerable efforts are being made to discover probiotics capable of preventing and managing obesity. In this study, we report the discovery of <i>Lactiplantibacillus plantarum</i> GBCC_F0227, isolated from fermented food, which exhibited superior triglyceride catabolism efficacy compared to <i>L. plantarum</i> WCSF1. Molecular analysis showed elevated expression levels of α/β hydrolases with lipase activity (abH04, abH08_1, abH08_2, abH11_1, and abH11_2) in <i>L. plantarum</i> GBCC_F0227 compared to <i>L. plantarum</i> WCFS1, demonstrating its enhanced lipolytic activity. In a high-fat-diet (HFD)-induced mouse obesity model, the administration of <i>L. plantarum</i> GBCC_F0227 mitigated weight gain, reduced blood triglycerides, and diminished fat mass. Furthermore, <i>L. plantarum</i> GBCC_F0227 upregulated adiponectin gene expression in adipose tissue, indicative of favorable metabolic modulation, and showed robust growth and low cytotoxicity, underscoring its industrial viability. Therefore, our findings encourage the further investigation of <i>L. plantarum</i> GBCC_F0227’s therapeutic applications for the prevention and treatment of obesity and associated metabolic diseases.