Generation of a hiPSC line ZZUNEUi007-A from a patient with hypertrophic cardiomyopathy caused by mutation in MYH7
oleh: Xiaowei Li, Yangyang Liu, Feifei Liu, Xiaojuan Wang, Mengduan Liu, Wenting Du, Jing Zhao, Mengyu Wang, Liang Hu, Chuchu Wang, Wanrong Fu, Jianzeng Dong, Xiaoyan Zhao
| Format: | Article |
|---|---|
| Diterbitkan: | Elsevier 2020-03-01 |
Deskripsi
Hypertrophic cardiomyopathy (HCM) is the most common monogenic cardiovascular disorder. In this study, we generated human induced pluripotent stem cells (iPSC) ZZUNEUi007-A from dermal fibroblasts of an HCM patient with the p. R663H (c. 1988 G > A) mutation in MYH7. The generated hiPSC line had normal karyotype, showed robust expression of pluripotency markers and could differentiate into all three germ layers in vivo.