Ubiquitin ligase STUB1 destabilizes IFNγ-receptor complex to suppress tumor IFNγ signaling
oleh: Georgi Apriamashvili, David W. Vredevoogd, Oscar Krijgsman, Onno B. Bleijerveld, Maarten A. Ligtenberg, Beaunelle de Bruijn, Julia Boshuizen, Joleen J. H. Traets, Daniela D’Empaire Altimari, Alex van Vliet, Chun-Pu Lin, Nils L. Visser, James D. Londino, Rebekah Sanchez-Hodge, Leah E. Oswalt, Selin Altinok, Jonathan C. Schisler, Maarten Altelaar, Daniel S. Peeper
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2022-04-01 |
Deskripsi
The IFNγ response pathway is associated with response to immunotherapy in cancer. Here the authors show that high levels of the IFNγ-receptor (IFNγ-R1) affect the outcome of immunotherapy in a context-dependent fashion and identify the E3 ubiquitin ligase STUB1 as a negative regulator of IFNγ-R1/JAK1 expression in cancer cells.