Progerinin, an optimized progerin-lamin A binding inhibitor, ameliorates premature senescence phenotypes of Hutchinson-Gilford progeria syndrome
oleh: So-mi Kang, Min-Ho Yoon, Jinsook Ahn, Ji-Eun Kim, So Young Kim, Seock Yong Kang, Jeongmin Joo, Soyoung Park, Jung-Hyun Cho, Tae-Gyun Woo, Ah-Young Oh, Kyu Jin Chung, So Yon An, Tae Sung Hwang, Soo Yong Lee, Jeong-Su Kim, Nam-Chul Ha, Gyu-Yong Song, Bum-Joon Park
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2021-01-01 |
Deskripsi
Kang, Park and colleagues develop and demonstrate the effects of a new drug candidate for treatment of Hutchinson-Gilford progeria syndrome pathologies. Progerinin extends the life span of mice used to model this disease and induces histological and physiological improvements.