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Posterior reversible encephalopathy syndrome (PRES) is an amalgam of clinical and radiological entities, which is reversible if diagnosed and treated promptly. It is characterized by varying neurological manifestation of seizure, headache, visual loss with typical magnetic resonance imaging findings of symmetric distribution of changes involving the parietooccipital lobes, which reflects vasogenic edema. The common causes include hypertension, renal failure, eclampsia, preeclampsia, sepsis, diabetic ketoacidosis, sepsis, cytotoxic drugs, and autoimmune disorders. Although it has been reported in association with diabetic ketoacidosis in few cases, its association with hyperglycemia in the absence of any other clinical or metabolic derangements is extremely rare. We report here a case of reversible blindness caused by hyperglycemia-induced PRES in a 21-year-old female.