FANCD2 promotes mitotic rescue from transcription-mediated replication stress in SETX-deficient cancer cells
oleh: Maha Said, Viviana Barra, Elisa Balzano, Ibtissam Talhaoui, Franca Pelliccia, Simona Giunta, Valeria Naim
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-12-01 |
Deskripsi
A synthetic lethal interaction is reported between the R-loop helicase Senataxin (SETX) and Fanconi anemia pathway proteins, with SETX deficiency increasing replication stress-induced chromosome fragility & activation of mitotic DNA synthesis.