Improving GENCODE reference gene annotation using a high-stringency proteogenomics workflow
oleh: James C. Wright, Jonathan Mudge, Hendrik Weisser, Mitra P. Barzine, Jose M. Gonzalez, Alvis Brazma, Jyoti S. Choudhary, Jennifer Harrow
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-06-01 |
Deskripsi
Identifying and annotating functional elements in the human genome remains a challenging but important task. Here the authors propose a priority annotation score to rank identifications and suggest how proteogenomics evidence can be interpreted and what additional information substantiates protein-coding potential for annotation.