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Three undescribed dihydrostilbene glycosides from leaves of Camellia oleifera Abel. And their anti-inflammatory activity
oleh: Yi Xu, Si-Qi Tang, Zong-Wu Suo, Kai-Xin Wei, Walter Luyten, Hao Huang, Xiao-Jun Li
Format: | Article |
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Diterbitkan: | Elsevier 2024-05-01 |
Deskripsi
Three previously unidentified dihydrostilbene glycosides, named oleiferaside A (1), oleiferaside B (2), and oleiferaside C (3), were discovered through a phytochemical exploration on Camellia oleifera Abel. leaves. Additionally, nine known secondary metabolites (4–12) were also identified. The undescribed secondary metabolites 1–3 were elucidated as 3,5-dimethoxydihydrostilbene 4′-O-α-l-arabinofuranosyl-(1 → 6)-β-d- glucopyranoside, 3,5-dimethoxydihydrostilbene 4′-O-α-l-arabinopyranosyl-(1 → 6)-β-d- glucopyranoside and 3,5-dimethoxydihydrostilbene 4′-O-β-d-apiofuranosyl-(1 → 6)-β-d- glucopyranoside, respectively. HR-MS and NMR spectroscopy were utilized for determining the structures of the isolates. The natural products were assessed for their anti-inflammatory effect using RAW264.7 macrophage stimulated by LPS. The findings demonstrated that compounds 1–4 exhibited inhibitory activities on NO and PGE2 production without causing cytotoxicity. These observations suggest that these compounds may have potential anti-inflammatory properties.