Chiral DNA sequences as commutable controls for clinical genomics
oleh: Ira W. Deveson, Bindu Swapna Madala, James Blackburn, Chris Barker, Ted Wong, Kirston M. Barton, Martin A. Smith, D. Neil Watkins, Tim R. Mercer
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-03-01 |
Deskripsi
Any DNA sequence can be represented by a chiral partner sequence – an exact copy arranged in reverse nucleotide order. Here, the authors show that chiral DNA sequence pairs share important properties and show the utility of synthetic chiral sequences (sequins) as controls for clinical genomics.