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In this case report, we describe a solitary lingual ganglioneuroma that presented as a painful submucosal mass in a 61-year-old male patient with a recent history of Hodgkin lymphoma treated with chemo-radiotherapy. There are multiple possible causes of submucosal masses of the tongue, and a differential diagnosis is necessary. Final diagnosis was made by biopsy and histopathological examination. Ganglioneuromas are benign tumors that rarely occur in the tongue, with only two such cases previously described in the English literature.