Striatal dopamine dissociates methylphenidate effects on value-based versus surprise-based reversal learning
oleh: Ruben van den Bosch, Britt Lambregts, Jessica Määttä, Lieke Hofmans, Danae Papadopetraki, Andrew Westbrook, Robbert-Jan Verkes, Jan Booij, Roshan Cools
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-08-01 |
Deskripsi
The mechanisms underpinning the variability in methylphenidate’s effects on cognition remain unclear. Here, the authors show that such effects reflect changes in striatal dopamine-related output gating of task-relevant cortical signals, and that these changes depend on baseline dopamine synthesis capacity.