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A mathematical model of a vector-borne disease involving variable human population is analyzed. The varying population size includes a term for disease-related deaths. Equilibria and stability are determined for the system of ordinary differential equations. If R0≤1, the disease-“free” equilibrium is globally asymptotically stable and the disease always dies out. If R0>1, a unique “endemic” equilibrium is globally asymptotically stable in the interior of feasible region and the disease persists at the “endemic” level. Our theoretical results are sustained by numerical simulations.