UFL1 promotes histone H4 ufmylation and ATM activation
oleh: Bo Qin, Jia Yu, Somaira Nowsheen, Minghui Wang, Xinyi Tu, Tongzheng Liu, Honglin Li, Liewei Wang, Zhenkun Lou
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-03-01 |
Deskripsi
Ufmylation is a ubiquitylation-like protein modification but only a few ufmylation substrates and functions have been discovered so far. Here, the authors demonstrate ufmylation of histone H4 upon DNA damage and show that this modification is involved in the amplification of ATM activation.