Framework nucleic acids as programmable carrier for transdermal drug delivery
oleh: Christian Wiraja, Ying Zhu, Daniel Chin Shiuan Lio, David C. Yeo, Mo Xie, Weina Fang, Qian Li, Mengjia Zheng, Maurice Van Steensel, Lihua Wang, Chunhai Fan, Chenjie Xu
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-03-01 |
Deskripsi
DNA nanostructures hold great promise for drug delivery, but systemic administration is problematic. Here, the authors demonstrate that framework nucleic acids (FNAs) improve drug accumulation in tumours in topical application and that penetration depth is controllable through adjusting FNA size.