Sequence-Based Identification of Metronidazole-Resistant Clostridioides difficile Isolates
oleh: Wiep Klaas Smits, Céline Harmanus, Ingrid M.J.G. Sanders, Lynn Bry, Grace A. Blackwell, Quinten R. Ducarmon, Eliane de Oliveira Ferreira, Ed J Kuijper
| Format: | Article |
|---|---|
| Diterbitkan: | Centers for Disease Control and Prevention 2022-11-01 |
Deskripsi
The plasmid pCD-METRO confers metronidazole resistance in Clostridioides difficile. We showed high sequence similarity among pCD-METRO plasmids from different isolates and identified pCD-METRO and associated metronidazole-resistant isolates in clinical and veterinary reservoirs in the Americas. We recommend using PCR or genomic assays to detect pCD-METRO in metronidazole-resistant C. difficile.