Polyoxygenated Diterpene Produced by The Indonesian Marine Sponge Callyspongiasp. as an Inhibitor of the Human Pancreatic Cancer Cells
oleh: VIQQI KURNIANDA, SUCI FARADILLA, SOFYATUDDIN KARINA, SRI AGUSTINA, MARIA ULFAH, CHITRA OCTAVINA, FARAH SYAHLIZA, MUHAMMAD RIZKI RAMADHAN, SYAHRUL PURNAWAN, MUSRI MUSMAN
| Format: | Article |
|---|---|
| Diterbitkan: | Indonesian Society for Microbiology 2020-01-01 |
Deskripsi
The bioactive compound from the Indonesian Marine SpongeCallyspongia sp.isolated based on bioassay-guided separation with several steps of chromatography has been done. There are 4 major compound known as isocopalane diterpene derivatives together with a plausible new compound, isocopalanol, a polyoxygenated isocopalane diterpene. Isocopalanol has molecular weight [M+H]+ 412.576 m/z indicate that the compound has molecular formula C24H44O5 determined by LCMS-ESI. This compound has bioactivity IC50 = 0.1 μg / mL against human pancreatic cancer cell.