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A mathematical model of HIV/AIDS and TB including its co-infections is formulated. We find the Equilibrium points and with the help of numerical simulation, we have analyze that the sub-models of TB, HIV/AIDS and its co-infections. The Caputo and Caputo Febrizo fractional derivative operator of order α ∈ (0, 1] is employed to obtain the system of fractional differential equations. Laplace Adomian Decomposition Method was successfully used for solving the different differential equations.Laplace transform is a perfect technique in various field of biological science,engineering,pure and applied mathematics. The latest technique Laplace Adomian Decomposition Method is employed on the developed fractional order model for the numerical solutions. Finally numerical simulations are also established to investigate the influence of the system parameter on the spread of disease and which show effect of fractional parameter α on our obtained solutions.