Discriminating cross-reactivity in polyclonal IgG1 responses against SARS-CoV-2 variants of concern

oleh: Danique M. H. van Rijswijck, Albert Bondt, Max Hoek, Karlijn van der Straten, Tom G. Caniels, Meliawati Poniman, Dirk Eggink, Chantal Reusken, Godelieve J. de Bree, Rogier W. Sanders, Marit J. van Gils, Albert J. R. Heck

Format: Article
Diterbitkan: Nature Portfolio 2022-10-01

Deskripsi

Profiling antibody repertoires using proteomic approaches may provide a way of screening for antibody cross-reactivity against SARS-CoV-2 variants. Here the authors use a IgG1 specific cleavage method to analyse the IgG1 repertoire within recovered patients and relate this to antibody binding and neutralisation.