Discriminating cross-reactivity in polyclonal IgG1 responses against SARS-CoV-2 variants of concern
oleh: Danique M. H. van Rijswijck, Albert Bondt, Max Hoek, Karlijn van der Straten, Tom G. Caniels, Meliawati Poniman, Dirk Eggink, Chantal Reusken, Godelieve J. de Bree, Rogier W. Sanders, Marit J. van Gils, Albert J. R. Heck
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-10-01 |
Deskripsi
Profiling antibody repertoires using proteomic approaches may provide a way of screening for antibody cross-reactivity against SARS-CoV-2 variants. Here the authors use a IgG1 specific cleavage method to analyse the IgG1 repertoire within recovered patients and relate this to antibody binding and neutralisation.