Structural and biochemical evidence supporting poly ADP-ribosylation in the bacterium Deinococcus radiodurans
oleh: Chao-Cheng Cho, Chia-Yu Chien, Yi-Chih Chiu, Meng-Hsuan Lin, Chun-Hua Hsu
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-04-01 |
Deskripsi
Poly-ADP-ribosylation (PARylation) is a well-known regulatory event in eukaryotes but has not yet been observed in bacteria. Here, the authors solve the structure of a bacterial PAR-glycohydrolase and provide evidence for a prokaryotic PARylation machinery involved in the response to genotoxic stress.