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Mucormycosis is a rare, emerging fungal infection, with high morbidity and mortality. Rhino-orbito-cerebral form is common. In the treatment of this form, it is recommended to apply amphotericin B and surgery together. However, despite these treatments, mortality is very high. We present a case of mucormycosis which we treated successfully with surgery for three times and simultaneously intravenous and nasal amphotericin B liopozomal application in our patient with acute lymphoblastic leukemia.