Mitochondrial DNA editing in mice with DddA-TALE fusion deaminases
oleh: Hyunji Lee, Seonghyun Lee, Gayoung Baek, Annie Kim, Beum-Chang Kang, Huiyun Seo, Jin-Soo Kim
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-02-01 |
Deskripsi
Split DddA-derived base editors fused to TALEs enable mitochondrial DNA editing. Here the authors demonstrate their use in mouse embryos with germline transmission.