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AIM: To observe the clinical effects of intravitreal injection of bevacizumab combined with complex trabeculectomy for neovascular glaucoma(NVG).<p>METHODS: Totally 46 patients with advanced NVG from February 2011 to September 2013 in our hospital were selected and divided into observation group(group A)and control group(group B), 23 cases in each group. Patients in group A were treated with intravitreal injection of bevacizumab combined with complex trabeculectomy. Patients in group B were treated with cyclocryotherapy. The visual acuity, intraocular pressure(IOP), degeneration of iris neovascularization and postoperative complications of the two groups were observed. All the patients were followed up for 12mo.<p>RESULTS: The postoperative IOP was decreased significantly compared with preoperative in the two groups, and the IOP level of group A was lower than that of group B, the difference was statistically significant(<i>P</i><0.05). Nineteen cases(83%)were treated successfully in group A, and 12 cases(52%)in group B, the difference was statistically significant(<i>χ</i>²=4.847, <i>P</i>=0.028).<p>CONCLUSION: Intravitreal injection of bevacizumab combined with complex trabeculectomy for neovascular glaucoma can effectively control IOP, and has higher successful rate.